Centre de Référence Maladies Rares

U1035 INSERM

Biotherapy of genetic diseases, inflammatory disorders and cancer (BMGIC)

FR: Biologie Fondamentale Appliquée à la Médecine

U1035Display navigation Aging and cancer FR / EN

2. Cancer and skin aging

EXPERTISE FIELD

Cancer cutané

Specialists in the study of DNA damage, oxidative stress and energy metabolism, we developed techniques to study the impact of these factors in skin cancer and aging.

We have developed several models (3D reconstructed skin, transgenic mice xenografts in mice) to evaluate whether the active ingredients acting on skin aging, or molecules acting preventively or curator on UVB-induced skin cancer.


SPECIAL SERVICES

Mitochondrie

  • Evaluation of the level of cytoplasmic ROS, mitochondrial or extracellular
  • Study of UV-induced apoptosis and DNA damage monolayer culture, skin model or 3D mouse skin
  • Evaluation of molecules modulating metabolism bioenergetic monolayer culture, 3D model of skin or skin of mice
  • Evaluation of preventive therapies and chemotherapies on UVB-induced model of skin cancer in mice
  • Evaluation of molecules modulating the aging on the skin of mice



Coordinator : Dr Hamid Reza REZVANI


see the publications related to this project

INSERM U1035! - University of Bordeaux
Work
146 rue Léo Saignat - PE building south zone, 4th floor
33000 Bordeaux
Aquitaine
France
Work +33 557 57 13 73/74
sarah.lesjean@inserm.fr