Centre de Référence Maladies Rares

U1035 INSERM

Biotherapy of genetic diseases, inflammatory disorders and cancers (BMGIC)

FR: Biologie Fondamentale Appliquée à la Médecine

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Hamid Reza REZVANI

INSERM Research Scientisthead of Dermatology team, hamid-reza.rezvani@u-bordeaux.fr

BIOSKETCH

PUBMED

  • Dr. Rezvani conducted his doctoral research at INSERM U1035 (Pr. De Verneuil), where he was trained in molecular and cellular biology. His research is mainly focused on the role of DNA repair system and reactive oxygen species (ROS) in the responses of keratinocytes to ultraviolet (UV) irradiation. During his postdoctoral training in the laboratory of Professor Bickers at Columbia University, he studied the relationship between DNA repair, levels of ROS and bioenergetic alterations during carcinogenesis using Xeroderma pigmentosum Type C ( XPC) as a model. After returning to the INSERM U1035 as Inserm researcher (CR), he continued his research on these topics. These studies have identified the NADPH oxidase-1 activation (NOX1) as the main output deficiency XPC. A selective inhibitor NOX-1 peptide nature, its design has resulted in a patent record in 2013, showed a striking effect on the development of squamous cell carcinoma (SCC) and premature skin aging in mice deficient in XPC.
    The main purpose of this group is now to understand the role of oxidative and energy metabolism in the UV-induced carcinogenesis and other pathophysiology of the skin, especially in vascular tumors (hemangioma) and pigmentation disorders (vitiligo) .

2006

  • Ph.D. thesis on biological and medical sciences (Bordeaux University)
    “Approche préclinique de transfert de gènes des enzymes antioxidants en vue de protection cutanée”

2007-2008

  • Postdoctoral fellow/ Superviser: Hubert de Verneuil
    Inserm U1035, Univ. Bordeaux, Bordeaux, France

2008-2009

  • Postdoctoral fellow/ Superviser: David R Bickers
    Department of Dermatology, Columbia Univ. Medical Center, New York, NY, US

2009-2011

  • Postdoctoral Scientist (ANR grant)/ Superviser: Alain Taieb
    Inserm U1035, Univ. Bordeaux, Bordeaux, France

PATENTS

  • SELECTIVE NOX-1 INHIBITOR PEPTIDES AND USESTHEREOF EP13150187

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