Centre de Référence Maladies Rares

U1035 INSERM

Biotherapy of genetic diseases, inflammatory disorders and cancers (BMGIC)

FR: Biologie Fondamentale Appliquée à la Médecine

U1035Display navigation INSERM U1035! FR / EN

Véronique TREZEGUET-BUSQUET

CNRS Research Scientist, veronique.trezeguet-busquet@u-bordeaux.fr

BIOSKETCH

Download his resume PUBMED

Peer-reviewed papers : 43
1. V. Trézéguet, M. Merle, J. C. Gandar & B. Labouesse. On the mechanism of tRNATrp aminoacylation catalysed by beef tryptophanyl-tRNA synthetase using presteady-state kinetics. FEBS Lett. 157,210-4 (1983).
2. D. Andrews, V. Trézéguet, M. Merle, P.-V. Graves, K. H. Muench & B. Labouesse. Tryptophanamide formation by Escherichia coli tryptophanyl-tRNA synthetase. Eur. J. Biochem. 146, 201-9 (1985).
3. M. Merle, V. Trézéguet, P. V. Graves, D. Andrews, K. H. Muench & B. Labouesse. Tryptophanyl adenylate formation by tryptophanyl-tRNA synthetase from Escherichia coli. Biochemistry 25, 1115-23 (1986).
4. V. Trézéguet, M. Merle, J. C. Gandar & B. Labouesse. Kinetic evidence for half-of-the-sites reactivity in tRNATrp aminoacylation by tryptophanyl-tRNA synthetase from beef pancreas. Biochemistry 25, 7125-36 (1986).
5. V. Trézéguet & B. Labouesse. The adenosine triphosphate-pyrophosphate isotopic exchange reaction, a tool for determination of tryptophan. Anal. Biochemistry 154, 618-623 (1986).
6. M. Merle, V. Trézéguet, J. C. Gandar & B. Labouesse. Effects of the ligands of beef tryptophanyl-tRNA synthetase on the elementary steps of the tRNATrp aminoacylation. Biochemistry 27, 2244-52 (1988).
7. H. Edwards, V. Trézéguet & P. Schimmel. An Escherichia coli tyrosine transfer RNA is a leucine-specific transfer RNA in the yeast Saccharomyces cerevisiae. Proc. Natl.Acad. Sci. USA 88, 1153-6 (1991).
8. V. Trézéguet, H. Edwards & P. Schimmel. A single base pair dominates over the novel identity of an Escherichia coli tyrosine tRNA in Saccharomyces cerevisiae. Mol. Cell. Biol. 11, 2744-51 (1991).
9. M. Garret, B. Pajot, V. Trézéguet, J. Labouesse, M. Merle, J. C. Gandar, J. P. Benedetto, M. L. Sallafranque, J. Alterio, M. Gueguen, C. Sarger, B. Labouesse & J. Bonnet. A mammalian tryptophanyl-tRNA synthetase shows little homology to prokaryotic synthetases but near identity with mammalian peptide chain release factor. Biochemistry 30, 7809-17 (1991).
10. G. Brandolin, A. Le Saux, V. Trézéguet, G. J.-M. Lauquin & P. V. Vignais Chemical, immunological, enzymatic, and genetic approaches to studying the arrangement of the peptide chain of the ADP/ATP carrier in the mitochondrial membrane. J. Bioenerg. Biomembr. 25, 459-72 (1993).
11. G. Brandolin, A. Le Saux, V. Trézéguet, P. V. Vignais & G. J.-M. Lauquin. Biochemical characterisation of the isolated Anc2 adenine nucleotide carrier from Saccharomyces cerevisiae mitochondria. Biochem. Biophys. Res. Commun. 192, 143-50 (1993).
12. P. Roux, A. Le Saux, C. Fiore, C. Schwimmer, A.C. Dianoux, V. Trézéguet, P. V. Vignais, G. J.-M. Lauquin & G. Brandolin. Fluorometric titration of the mitochondrial ADP/ATP carrier protein in muscle homogenate with atractyloside derivatives. Anal. Biochemistry 234, 31-37 (1996).
13. N. Couzin, V. Trézéguet, A. Le Saux, G. J.-M. Lauquin. Cloning of the gene encoding the mitochondrial adenine nucleotide carrier of Schizosaccharomyces pombe by functional complementation in yeast. Gene 171, 113-117 (1996).
14. A. Le Saux, P. Roux, V. Trézéguet, C. Fiore, C. Schwimmer, A.C. Dianoux, P. V. Vignais, G. Brandolin & G. J.-M. Lauquin. Conformational changes of the yeast mitochondrial ADP/ATP carrier studied through its intrinsic fluorescence. 1. The tryptophanyl residues of the carrier can be mutated without impairing protein activity. Biochemistry 35,16116-16124 (1996).
15. P. Roux, A. Le Saux, V. Trézéguet, C. Fiore, C. Schwimmer, A.C. Dianoux, P. V. Vignais, G. J.-M. Lauquin & G. Brandolin. Conformational changes of the yeast mitochondrial ADP/ATP carrier studied through its intrinsic fluorescence. 2. Assignment of tryptophanyl residues of the carrier to the responses to specific ligands. Biochemistry 35: 16125-16131 (1996).
16. C. Fiore, V. Trézéguet, A. Le Saux, P. Roux, C. Schwimmer, A.-C. Dianoux, F. Noël, G. J.-M. Lauquin, G. Brandolin & P. V. Vignais. The mitochondrial ADP/ATP carrier : structural, physiological and pathological aspects. Biochimie 80:137-150 (1998).
17. V. Trézéguet, I. Zeman, C. David, G. J.-M. Lauquin, and J. Kolarov. Expression of the ADP/ATP carrier encoding genes in aerobic yeasts; phenotype of an ADP/ATP carrier deletion mutant of Schizosaccharomyces pombe. Biochim. Biophys. Acta 1410: 229-236 (1999).
18. C. Fiore, V. Trézéguet, P. Roux, C. Schwimmer, F. Noël, A.-C. Dianoux, G. J.-M. Lauquin, G. Brandolin & P. V. Vignais. The mitochondrial ADP/ATP carrier in the cell economy. Biochemistry, genetics and pathophysiology. In Mitochondrial diseases. Models and Methods. Lestienne P. (Ed) Springer-Verlag Press, Heidelberg, pp 143-158 (1999).
19. V. Trézéguet, A. Le Saux, C. David, C. Gourdet, C. Fiore, A.-C. Dianoux, G. Brandolin & G. J.-M. Lauquin. A covalent tandem dimer of the mitochondrial ADP/ATP carrier is functional in vivo. Biochim. Biophys. Acta 1457: 81-83 (2000).
20. C. Fiore, V. Trézéguet, P. Roux, A. Le Saux, F. Noël, C. Schwimmer, D. Arlot, A.-C. Dianoux, G. J.-M. Lauquin & G. Brandolin. Purification of histidine-tagged mitochondrial ADP/ATP carrier : influence of the conformational states of the C-terminal region. Protein Expression and Purification 19: 57-65 (2000).
21. A.C. Dianoux, F. Noël, C. Fiore, V. Trézéguet, S. Kieffer, M. Jaquinot, G. J.-M. Lauquin, G. Brandolin. Two distinct regions of the yeast mitochondrial ADP/ATP carrier are photolabeled by a new ADP analogue : 2-azido-3’-O-naphtoyl[32P]ADP. Identification of the binding segments by mass spectrometry. Biochemistry 37: 11477-11487 (2000).
22. V.-A. Lorenz, J. Villaverde, V. Trézéguet, G. J.-M. Lauquin, G. Brandolin, E. Padros. The secondary structure of the inhibited mitochondrial ADP/ATP transporter from yeast analyzed by FTIR spectroscopy. Biochemistry 40: 8821-8833 (2001).
23. C. Fiore, D. Arlot-Guilligay, V. Trézéguet, G. J.-M. Lauquin, G. Brandolin. Fluorometric detection of ADP/ATP carrier deficiency in human muscle. Clin Chim Acta. 311(2):125-35 (2001).
24. C. De Marcos Lousa, V. Trézéguet, A.-C. Dianoux, G. Brandolin G. J.-M. Lauquin. The human mitochondrial ADP/ATP carriers : kinetic properties and biogenesis of wild type and mutant proteins in the yeast S. cerevisiae. Biochemistry, 41(48):14412-14420 (2002).
25. S. D. Dyall, S. C. Agius, C. De Marcos Lousa, V. Trézéguet, K. Tokatlidis. The dynamic dimerisation of the yeast ADP/ATP carrier in the inner mitochondrial membrane is affected by conserved cysteine residues. J. Biol. Chem. 278(29): 26757-64 (2003).
26. I. Zeman, C. Schwimmer, V. Postis, G. Brandolin, C. David, V. Trézéguet, G. J.-M. Lauquin. Four Mutations in T ransmembrane Domains of the Mitochondrial ADP/ATP Carrier Increase Resistance to Bongkrekic Acid. J. Bioenerg. Biomembr. 35(3): 243-256 (2003)
27. V. A. Lorenz-Fonfria, J. Villaverde, V. Trézéguet, G. J.-M. Lauquin, G. Brandolin, E. Padros. Structural and Functional Implications of the Instability of the ADP/ATP Transporter Purified from Mitochondria as Revealed by FTIR Spectroscopy. Biophys J. 85(1): 255-66 (2003).
28. E. Pebay-Peyroula, C. Dahout-Gonzalez, R. Kahn, V. Trézéguet, G. J.-M. Lauquin, G. Brandolin Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside. Nature, 426: 39-44 (2003).
29. C. De Marcos Lousa, Trézéguet V., David C., Postis V., Arnou B., Pebay-Peyroula E., Brandolin G., Lauquin G. J.-M. Valine 181 is critical for the nucleotide exchange activity of human mitochondrial ADP/ATP carriers in yeast. Biochemistry 44 : 4342-4348 (2005).
30. V. Postis, C. De Marcos Lousa, B. Arnou, G. J.-M. Lauquin, V. Trézéguet. Subunits of the yeast mitochondrial ADP/ATP carrier: cooperation within dimer. Biochemistry, 44 : 14732-14740 (2005).
31. H. Nury, C. Dahout-Gonzalez, V. Trézéguet, G. J.-M. Lauquin, G. Brandolin, E. Pebay-Peyroula. Structural basis for lipid mediated interactions between mitochondrial ADP/ATP carrier monomers. FEBS Lett., 579 : 6031-6036 (2005).
32. C. Dahout-Gonzalez, Nury H., Trézéguet V., Lauquin G. J.-M., Pebay-Peyroula E., Brandolin G. Molecular, functional, and pathological aspects of the mitochondrial ADP/ATP carrier. Physiology (Bethesda) 21, 242-9 (2006).
33. B. Clémençon, M. Rey, A.-C. Dianoux, V. Trézéguet, G. J.-M. Lauquin, G. Brandolin, L. Pelosi. Structure-function relationships of the C-terminal end of the Saccharomyces cerevisiae ADP/ATP carrier isoform 2. J. Biol. Chem., 283, 11218-11225 (2008).
34. V. Trézéguet, L. Pelosi, G. J.-M. Lauquin, G. Brandolin. The mitochondrial ADP/ATP carrier: functional and structural studies in the route of elucidating pathophysiological aspects. J. Bioenerg. Biomembr. 40, 435-443 (2008).
35. C. David, B. Arnou, J.-F. Sanchez, L. Pelosi, G. Brandolin, G. J.-M. Lauquin, V. Trézéguet. Two residues of a conserved aromatic ladder of the mitochondrial ADP/ATP carrier are crucial to nucleotide transport. Biochemistry, 47, 13223-13231 (2008).
36. M. Rey, P. Man, B. Clémençon, V. Trézéguet, G. Brandolin, E. Forest, L. Pelosi. Conformational dynamics of the bovine mitochondrial ADP/ATP carrier isoform 1 revealed by hydrogen/deuterium exchange coupled to mass spectrometry. J. Biol. Chem., 285, 34981-34990 (2010).
37. B. Clémençon, M. Rey, V. Trézéguet, E. Forest, L. Pelosi. Yeast ADP/ATP Carrier Isoform 2: conformational dynamics and the rôle of the RRRMMM signature sequence methionines. J. Biol. Chem., 286, 36119-31131 (2011).
38. J. F. Sanchez, B. Kauffmann, A. Grélard, C. Sanchez, V. Trézéguet, I. Huc, G. J.-M. Lauquin, Unambiguous structure of atractyloside and carboxyatractyloside. Bioorg. Med. Chem. Lett., 22, 2973-2975 (2012).
39. M. Babot, C. Blancard, P. Ludovic Pelosi, G J.-M. Lauquin, and V. Trézéguet, The transmembrane prolines of the mitochondrial ADP/ATP carrier are involved in nucleotide binding and transport and in its biogenesis. J. Biol. Chem., 287(13):10368-78 (2012).
40. M. Babot, C. Blancard, I. Zeman, G. J.-M. Lauquin, V. Trézéguet. Mitochondrial ADP/ATP carrier: preventing conformational changes by point mutations inactivates nucleotide transport activity. Biochemistry. 51, 7348-7356 (2012). Correction in Biochemistry.55, 2422 (2016).
41. B. Clémençon, M, Babot, and V. Trézéguet, The mitochondrial ADP/ATP carrier (SLC25A4): pathological implications of its dysfunction. Mol. Aspects Med. 34, 485-493 (2013).
42. G. Gouspillou, I. Bourdel-Marchasson, R. Rouland, G. Calmettes, M. Biran, V. Deschodt-Arsac, S. Miraux, E. Thiaudiere, P. Pasdois, D. Detaille, J.-M. Franconi, M. Babot, V. Trézéguet, L. Arsac, P. Diolez. Mitochondrial energetics is impaired in vivo in aged skeletal muscle. Aging Cell. 13, 39-48 (2014).
43. F. Cartier, Indersie E, Lesjean S, Charpentier J, Hooks KB, Ghousein A, Desplat A, Dugot-Senant N, V. Trézéguet, Sagliocco F, Hagedorn M, Grosset CF. New tumor suppressor microRNAs target glypican-3 in human liver cancer. Oncotarget. 8, 41211-41226 (2017).

Books and chapters : 6
1. G. Brandolin, A. Le Saux, P. Roux, V. Trézéguet, C. Fiore, C. Schwimmer, A.C. Dianoux, G. J.-M. Lauquin & P. V. Vignais. Conformational changes of the beef heart and yeast mitochondrial ADP/ATP carrier. Progress in Cell Research 5, 71-75 (1995).
2. G. Brandolin, A. Le Saux, P. Roux, V. Trézéguet, C. Fiore, C. Schwimmer, A.C. Dianoux, G. J.-M. Lauquin & P. V. Vignais. The ATP/ADP transport system ,a paradigm of metabolite transport in mitochondria. In Organellar Ion Channels and Transporters (Ed) D. E. Clapham & B. E. Ehrlich, pp 173-185 (1996).
3. C. Fiore, V. Trézéguet, P. Roux, C. Schwimmer, F. Noël, A.-C. Dianoux, G. J.-M. Lauquin, G. Brandolin & P. V. Vignais. The mitochondrial ADP/ATP carrier in the cell economy. Biochemistry, genetics and pathophysiology. In Mitochondrial diseases. Models and Methods. Lestienne P. (Ed) Springer-Verlag Press, Heidelberg, pp 143-158 (1999).
4. C. Fiore, V. Trézéguet, G. J.-M Lauquin., G. Brandolin, Pierre Vignais. Transporteur mitochondrial d’ADP/ATP. In Les maladies mitochondriales, Annales de l’Institut Pasteur/actualités, vol. 9/10, pp 101-112 (2001).
5. H. Nury, C. Dahout-Gonzalez, V. Trézéguet, G. J.-M. Lauquin, G., Brandolin, and E. Pebay-Peyroula. Relations between structure and function of the mitochondrial ADP/ATP carrier. Annual Review Biochemistry, 75, 713-741 (2006).
6. B. Arnou, C. Dahout-Gonzalez, L. Pelosi, G. J.-M. Lauquin, G. Brandolin, V. Trézéguet. Native membrane proteins versus yeast recombinant: an example, the mitochondrial ADP/ATP carrier. In Membrane Protein Structure Determination, Methods Mol. Biol., 654, 19-28 (2010).

Back to organigramme

INSERM U1035! - University of Bordeaux
Work
146 rue Léo Saignat - PE building south zone, 4th floor
33000 Bordeaux
Aquitaine
France
Work +33 557 57 13 73/74
sarah.lesjean@inserm.fr