Centre de Référence Maladies Rares

U1035 INSERM

Biotherapy of genetic diseases, inflammatory disorders and cancers (BMGIC)

FR: Biologie Fondamentale Appliquée à la Médecine

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Immuno-Dermatology team
Project 3.2

Inflammatory Skin Diseases: psoriasis, atopic dermatitis, alopecia aerate

keywords: psoriasis, atopic dermatitis, alopecia areata

Description:

The immuno-dermatology team is currently conducting independent or collaborative projects to better understand the immune mechanisms and the close interactions between the immune system and the epidermal barrier during chronic inflammatory skin disorders such as psoriasis, atopic dermatitis and alopecia aerata.
In collaboration with Dr Mei Li, (IGBMC: Institut de Génétique et Biologie Moléculaire et Cellulaire, Strasbourg, France), we have recently demonstrated a new mechanism of a molecule classically used for the treatment of psoriasis (a frequent and chronic skin inflammatory associated with erythematous plaques with flakes): calcipotriol (Vitamin D analogue). Calcipotriol used alone or in combination with corticosteroid efficiently disrupts the IL-36 and IL-23/IL-17 positive feedback loop, thus revealing a mechanism underlying the superior efficacy of calcipotriol and corticosteroid combination therapy for psoriasis.
Regarding Atopic Dermatitis: a skin chronic disorders responsible for major pruritus affecting the quality of life of patients; a collaborative project is currently conducted with Dr Charles Bodet (LITEC: Laboratoire Inflammation, Tissus épithéliaux et Cytokines, Université de Poitiers, France). This project received the support of “Région Nouvelle-Aquitaine” and will better decipher the complex interaction between the immune response, the skin barrier and the microbiota. Moreover another collaborative project is also conducted with Dr Mei Li (IGBMC) on the role of a small population of immune cells called “Basophils”.

Related publications:

  • Disrupting the IL-36 and IL-23/IL-17 loop underlies the efficacy of calcipotriol and corticosteroid therapy for psoriasis. Germán B, Wei R, Hener P, Martins C, Ye T, Gottwick C, Yang J, Seneschal J, Boniface K, Li M1. JCI insight ()
  • OX40L/OX40 axis impairs follicular and natural Treg function in human SLE. C. Jacquemin, J.F. Augusto, M. Scherlinger, N. Gensous, E. Forcade, I. Douchet, E. Levionnois, C. Richez, E. Lazaro, P. Duffau, M.E. Truchetet, J. Seneschal, L. Couzi, J.L. Pellegrin, J.F. Viallard, T. Schaeverbeke, V. Pascual, C. Contin-Bordes, P. Blanco. JCI Insight ()
  • Inflammasome Activation Characterizes Lesional Skin of Folliculitis Decalvans. A. Eyraud, B. Milpied, D. Thiolat, A.S. Darrigade, K. Boniface, A.Taïeb, J. Seneschal Acta Dermatologie Venereol ()
  • Childhood chronic prurigo: Interest in patch tests and delayed-reading skin prick tests to environmental allergens. C. Maridet, M. Perromat, J. Miquel, C. Chiaverini, D; Bessis, A. Lasek, M. Piram, A. Bursztejn, C. Abasq, A. Phan, L. Martin, B. Bréchat, J.H.Chong, J. Seneschal, A. Taïeb, F. Boralevi; Groupe de Recherche Clinique de la Société Française de Dermatologie Pédiatrique. J Allergy Clin Immunol ()
  • Topical corticosteroid phobia in atopic dermatitis: International feasibility study of the TOPICOP score. Stalder JF, Aubert H, Anthoine E, Futamura M, Marcoux D, Morren MA, Trzeciak M, Szalai Z, Veres K, Deleuran M, Vestergaard C, Boralevi F, Chu CY, De Raeve L, Svensson Å, Fölster-Holst R, Buchner M, Takaoka R, Aoki V, Chernyshov P, Chernyshova L, Murrell DF, Zhao C, Mckinster CD, Von Kobyletzky L, Eichenfield L, Totri C, Lio P, Seneschal J, Moret L, Barbarot S. Allergy ()
  • Platelets Induce Thymic Stromal Lymphopoietin Production by Endothelial Cells: Contribution to Fibrosis in Human Systemic Sclerosis. Truchetet ME, Demoures B, Eduardo Guimaraes J, Bertrand A, Laurent P, Jolivel V, Douchet I, Jacquemin C, Khoryati L, Duffau P, Lazaro E, Richez C, Seneschal J, Doutre MS, Pellegrin JL, Constans J, Schaeverbeke T, Blanco P, Contin-Bordes C; Fédération Hospitalo-Universitaire ACRONIM. Arthritis Rheumatol ()
  • CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice. Poissonnier A, Sanséau D, Le Gallo M, Malleter M, Levoin N, Viel R, Morere L, Penna A, Blanco P, Dupuy A, Poizeau F, Fautrel A, Seneschal J, Jouan F, Ritz J, Forcade E, Rioux N, Contin-Bordes C, Ducret T, Vacher AM, Barrow PA, Flynn RJ, Vacher P, Legembre P. Immunity ()
  • OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response. Jacquemin C, Schmitt N, Contin-Bordes C, Liu Y, Narayanan P, Seneschal J, Maurouard T, Dougall D, Davizon ES, Dumortier H, Douchet I, Raffray L, Richez C, Lazaro E, Duffau P, Truchetet ME, Khoryati L, Mercié P, Couzi L, Merville P, Schaeverbeke T, Viallard JF, Pellegrin JL, Moreau JF, Muller S, Zurawski S, Coffman RL, Pascual V, Ueno H, Blanco P. Immunity ()

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