Centre de Référence Maladies Rares


Biotherapy of genetic diseases, inflammatory disorders and cancers (BMGIC)

FR: Biologie Fondamentale Appliquée à la Médecine

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CRISPR and Translational Medicine congress

The 1st CRISPR and translational medicine meeting will be held on march 31st and April 1st in Bordeaux.

CRISPR is one of the most powerful discoveries of the last decade and the scientific program of the congress is organized in six sessions dealing with major aspects of current developments:

  1. CRISPR for Neuromuscular Disorders
  2. Engineered cellular models of genetic disease (cell lines, primary cells, iPSCs)
  3. Engineered animal models of genetic disease
  4. Gene therapy
  5. Safety (off-targets, genotoxicity, immunity)
  6. New CRISPR tools

The CRISPR-Cas9 technology has revolutionized genome edition approaches in the last few years. It is used to model genetic diseases in both in vitro cell lines or primary cells (sessions 1 and 2) and in vivo animal models (session 3). First therapeutic trials in humans have been undertaken (session 4), further strengthening the clinical prospects of the technology. Meanwhile, the intensive use of CRISPR tool in research labs has revealed off-target effects with unwanted genetic modifications (session 5), and many current researches are focused on the improvement of DNA targeting and cutting action of CRISPR tools in order to overcome these drawbacks and develop new applications (session 6).

A Round Table (in french), presenting the CRISPR technology with societal and ethical aspects, will be scheduled on Friday evening.

Deadline for abstrac: 15th february

Deadline for inscription: 15th march


4th Symposium of the Occitanie Network on Monocytes-Macrophages

SOMM 2021

Since its launch in 2017 in Montpellier, the SoMM (Symposium of the Occitanie Network on Monocytes-Macrophages) brings together every year about a hundred academic and private actors around a common axis of interest focused on Monocytes/Macrophages in order to create links, promote exchanges of skills and develop new collaborations around this specific axis.

Involved in tissue homeostasis and the physiological and pathological inflammatory response, Monocytes/Macrophages are present in all human pathologies and represent an interesting target in clinical practice, as diagnostic markers, possibly prognostic markers of severity, and for the evaluation of innovative therapies, but also as therapeutic targets. Different fields of Monocyte/Macrophage biology are explored during this symposium, notably among those represented in the research institutes of the Macrophage Club of the Occitanie Region expanded in Bordeaux, Marseille and Nice. Their role in tissue homeostasis, in inflammation and its resolution, in tissue regeneration, but also in metabolic, infectious and autoimmune diseases, or in cancers, in humans but also through their study in various experimental models (in mice but also in zebrafish) will be discussed.

Bordeaux local organizing comittee
Claudine Boiziau (INSERM, BioTis)
Aksam Merched (INSERM, BMGIC)
Agnès Nadjar (INRA,NutriNeuro)
Florence Ottones (CNRS, CRMSB)
Sarah Lesjean (Gestion) (Inserm, BMGIC)

Website for the 2021 symposium, under construction : https://somm2021.sciencesconf.org

CRISPR and Translational Medicine congress

CRISPR and Translational Medicine congress is postpone in spring 2022

Congrès Annuel de Recherche Dermatologique (C.A.R.D.)

Le Congrès Annuel de Recherche Dermatologique (C.A.R.D.), dont la langue officielle est le français, est ouvert à tous les biologistes et scientifiques, du domaine public ou privé, intéressés par la recherche dermatologique. Il a lieu en France ou en pays francophone, une fois par an, chaque année dans une ville différente.

Le CARD 2021 aura lieu en version virtuelle le 1er Juillet 2021.

Au programme :

  • Homéostasie cutanée
  • Immuno-inflammation
  • Oncologie
  • Symposium « méridien » sponsorisé par Leo Pharma.

Vous pouvez d’ores et déjà soumettre votre résumé, et ce jusqu’au 15 mai 2021.


thesis defense Farah Rahal

Thesis defense Farah Rahal, PhD student MIRCADE team
Thursday 27th May at 9:30, videoconference


thesis defense Florence Prat

Thesis defense Florence PRAT, biotherapy team.
Title : “Les solutions pour prévenir la génotoxicité du système CRISPR-Cas9”.
Wednesday 16 December, 14h

Thesis defense Solène Fernandez

Thesis defense Solène FERNANDEZ, Hematology team.
Title : “Microenvironnement médullaire et résistance à la Midostaurine dans les leucémies aiguës myéloïdes FLT3-ITD: Identification de cibles thérapeutiques par criblage génomique fonctionnel”.
Friday 11 December, 14h

4ème Symposium du Réseau Monocytes-Macrophages

Postpone in november 2021

12ème colloque du Club des Belles Souris

The 12e “colloque du Club des Belles Souris” will be in videoconference the 24 November 2020
Free but mandatory inscription in this link


CRISPR and Translational Medicine congress - Postpone

The CRISPR and Translational Medicine congress is postpone in 2021

Annueal SFTCG meeting

The annual SFTCG (Société Française de Thérapie Cellulaire et Génique) meeting will take place at Lyon ENS the 11 – 13 march 2020.

François Moreau-Gaudry, unit director, head of Biotherapy team and vectorology core facility is member of the organisation committee.

A special opening to the civil society such as patients will be organized and 7 scientific sessions :

- Gene editing in gene therapy
- In vivo gene therapy
- Innovative approaches
- Cancer gene therapy
- Stem Cells and iPS
- Towards clinical trials
- Clinical trials & more

The additional informations and inscriptions is in this link

Abstract submission deadline : February 1
Poster / Oral notifications : February 20
Abstracts live on the website : March 11


Bordeaux Research In Cancer BRIC. Scientific meeting

BRIC scientific meeting

1st Scientific meeting of the future unit Inserm : Bordeaux Research In Cancer (BRIC).
Ondotologie building, Amphi B (Carreire campus, Bordeaux university)
Friday 21 February, 11:30-13:00



ESDR meeting 2019 - Bordeaux

The European Society for Dermatological Research (ESDR) meeting will take place in Bordeaux in 2019 from 18 to 21 september

CRISPR-Cas9 molecular scissors: a bit too sharp?

New article by the Biotherapy team published in Nature Communications.
Click for more detail



FR Transbiomed conference : Hervé Seitz, invited by François Moreau-Gaudry

The 26 November 2018 from 11:00 to 12:00.

Hervé Seitz, Montpellier (IGH). Impact systémique des petits ARN régulateurs

Gene regulation is traditionally assessed by molecular assays, probing the physical interaction between regulators and their targets (transcription factors with promoters, RNA-binding proteins with mRNAs, …). The advent of high-throughput techniques now allows a sensitive detection of molecular interactors for the regulators of interest – and these experiments usually identify hundreds or thousands of targets per regulator. This is particularly true for microRNAs (“miRNAs”), which are therefore believed to control most coding genes in mammals. Functional importance of these interactions is apparently confirmed by comparative genomics, which suggests that many miRNA binding sites are conserved in evolution. Yet several observations suggest that miRNAs do not have such a broad biological effect; in particular, miRNA-guided repression is surprisingly small (targets are usually repressed less than 2-fold, and gene activity is typically insensitive to such small changes in gene expression). We thus decided to revisit the biological relevance of miRNA/target interactions, and our results are indeed inconsistent with the notion that miRNAs regulate functionally so many genes. It appears that molecular biology techniques, as well as computational predictions, tend to over-estimate broadly the miRNA target pool, and just a subset of the identified targets are really, functionally targeted. Other regulatory events appear to be buffered by homeostasis, and they are inconsequential at the macroscopic scale. These notions are generalizable to every type of gene regulator, and they could promote a profound redefinition of “gene regulation”.


2nd symposium of inflammatory and cancer in Dermatology in Nouvelle-Aquitaine

in the University of Poitiers.

registration at this link

Poster awards in International congress of SIOP for Christophe Grosset

During the 50st Congress of the International Society of Pediatric Oncology (SIOP) in November 2018, in Kyoto, Japan, Dr Christophe Grosset, who heads the MiRCaDe team, received a poster award at the “Solid and CNS Tumours: Clinical” Session.
At this occasion, Dr Christophe Grosset presented his last results about the transcriptional study of 25 hepatoblastoma samples by RNA-seq. This work, published in Hepatology journal (https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep.29672) led to the design of a new 4-gene signature that can be used by pathologists for the stratification of tumors, the identification of a new oncogenic pathway (e.g. Fanoni Anemia pathway) and a novel treatment option using Velcade for patients with a C2A-type proliferative hepatoblastoma.


SCIENTIFIC MEETING Fondation René Touraine 2018


Friday 16th November 2018, in Paris,
at Musée des Moulages de l’Hôpital Saint-Louis,
1 avenue Claude Vellefaux – 75010 Paris.

Invited speackers :
Ryan R DRISKELL (Pullman, US)
Rachel WATSON (Manchester, United Kingdom)
Gary FISHER (Ann Arbor, US)
Jose Luis JORCANO (Madrid, Spain)
Gian-Paolo DOTTO (Lausanne, Switzerland)
Beate ECKES (Cologne, Germany)
Teresa ODORISIO (Rome, Italy)
Jagdeep NANCHAHAL (Oxford, United Kingdom)

Fondation René Touraine, Hôpital St Louis, Pavillon Bazin,
1, avenue Claude Vellefaux – F-75475- PARIS cedex 10 – (France)
Téléphone : 01 53 72 20 60 Fax : 01 53 72 20 61 courriel: christina.pitton@fondation-r-touraine.org
Or in the website : http://www.fondation-r-touraine.org/Journees-scientifiques#sommaire


A trophy for Aksam Merched

Aksam Merched Trophy

The 20th of octobre in Tripoli (Liban), Pr. Aksam Merched, from MiRCaDe team, receive a trophy during the 24th Congress of Surgical Society of North Leabanon, from the organizing committee and his president for accepting their invitation and giving a lecture on immunotherapy of cancer in a special session dedicated to therapeutic innovations.

Alain Taïeb will be awarded the first new ESPCR Award at the EPSCR meeting

Alain Taïeb will be awarded the first new ESPCR Award at the EPSCR meeting on 24 september in Rennes. ESPCRblog

The European Society for Pigment Cell Research (ESPCR) is a scientific society dedicated to understanding the biology of the pigment cells, melanocytes, from normal to pathological development.

The 21th ESPCR Meeting will be hosted in Rennes, the capital of Brittany in France on 24 to 27 september 2018.

It aims at deciphering the biology of the melanocyte and its ecosystem, the better to understand its dysfunction and pathological evolution.

To this end, the 21th ESPCR Meeting will bring together competencies from basic science to disease. It will also be a unique opportunity to envision the forthcoming new therapeutic approaches.

To promote science, the ESPCR meeting includes two keynote lectures, guest lectures from internationally recognized scientists, oral presentations from peer-reviewed abstracts, poster sessions and an Innovation pitches session.

Social events are organized to promote networking and very importantly, the ESPCR sponsors several travel awards.

Prof Alain Taïeb, Chairman of the International Society of Atopic Dermatitis (ISAD)

Prof Alain Taïeb is elected Chairman of the International Society of Atopic Dermatitis (ISAD)

Bordeaux Cell Biology Gathering (BCBG)

the second edition of BCBG will take place the 4th of April at the Domaine du Haut-carré (Talence) from 9 a.m to 5 p.m.

The meeting is free but inscription is mandatory

More info :

Conference Pr David Kelsell invité par Alain Taïeb

Conférence FR Transbiomed : Pr David Kelsell invité par Alain Taïeb, jeudi 1er mars 2018 à 11h
iRhom2 and the keratinocyte stress response

David Kelsell, Professor of Human Molecular Genetics, Blizard Institute, Barts and the London Medical School, Queen Mary University of London

Biosketch :
My research largely focuses on the molecular and cellular mechanisms underlying inherited non-syndromic and syndromic skin disease including keratodermas, ichthyoses and atopic eczema. In addition, this work has highlighted the importance of studying skin disease to understand non-cutaneous conditions such as oesophageal cancer, hearing loss and cardiomyopathy. I am Deputy Dean for Research of Barts and the London Medical School, and I am President-Elect of the European Society of Dermatological Research. I was awarded the 2016 CHANEL CERIES research award.

Abstract : The ability of cells and tissues to withstand and respond to a variety of stressors is fundamental to life. In mammals, the skin plays a unique role in the defence against external damage, pathogens and allergens, and therefore displays many specialised adaptations to environmental stress. In particular, the epidermis of palmoplantar (palm and sole) regions is uniquely adapted to withstand remarkable physical stress. We have identified dominantly-inherited point mutations in the gene encoding iRhom2 (RHBDF2) associated with Tylosis with Oesophageal Cancer, a syndrome in which affected individuals develop focal palmoplantar keratoderma (PPK) and have a very high risk of oesophageal squamous cell carcinoma. We have shown these point mutations to result in gain-of-function of the iRhom2 protein, a catalytically inactive member of the rhomboid family. Based on multiple lines of evidence generated by our laboratory, this proposal hypothesises that iRhom2 functions as a major regulator of the response to cellular stress and disease in the epidermis. Our work has shown iRhom2 to be an important regulator of keratin dynamics, the epidermal barrier and growth factor / cytokine production via regulation of the sheddase ADAM17. This talk will discuss the role of iRhom2 in regulating epidermal keratin dynamics in response to stress and will describe signalling pathways both upstream and downstream of iRhom2.

conference Jeremy Di Domizio

Jeremy Di Domizio

conference FR Transbiomed :
Jeremy Di Domizio invited by Katia Boniface
tuesday, 20 february, 14h
conference room at the Plateforme de Génomique Fonctionnelle, Carreire, University of Bordeaux.

Jeremy Di Domizio
University Hospital of Lausanne CHUV, Lausanne, Switzerland

Pathogenic role of interleukin (IL)-26 producing Th17 cells in the acute forms of psoriasis

Chronic plaque-type psoriasis is a skin inflammatory disease driven by IL-17-producing Th17 cells. In addition to IL-17, Th17 cells in psoriasis produce other cytokines including interleukin (IL)-26, a member of IL-10 cytokine family. However, whether the production of IL-26 by Th17 cells plays a pathogenic role in psoriasis is unknown. By comparing IL-26 and IL-17 expression in psoriatic skin samples, we found that high IL-26 and low IL-17 were detected in acute forms of psoriasis, including erythrodermic and guttate-type, whereas low IL-26 and high IL-17 mainly associated with chronic plaque psoriasis. The dichotomy of IL-26 and IL-17 expression was confirmed in T cells infiltrating psoriatic skin lesions and circulating in the blood where IL-26 producing T cells and IL-17-producing T cells represented distinct cell populations within CXCR3– CCR4+ CCR6+ Th17 cells. Finally, we assessed the pathogenic role of IL-26 in psoriasis by using IL-26-transgenic mice. Skin injury of IL-26 transgenic mice triggered an inflammatory response and a skin phenotype resembling psoriasis, suggesting a pathogenic role in the induction of the disease. Together, our findings indicate that IL-26 is expressed by a distinct subset of Th17 cells in acute forms of psoriasis, where it may drive the inflammatory process and disease development.

5th World Congress scleroderma

Scleroderma The 5th World Congress will be in Bordeaux from 15 to 18 February 2018.

Affiche sclérodermie

Conference Antonin Marchais invited by C. Grosset

Conference FR Transbiomed.
Antonin Marchais, invited by Christophe Grosset.
Conference room of IBGC, 11h

“Characterization of phased siRNA biogenesis in mammals and plants from deep-sequencing data”
Antonin Marchais, Département de cancérologie de l’enfant et l’adolescent. Equipe SPIAJA – Institut Gustave Roussy

Over the past few years, important new aspects of small RNA biogenesis, maturation, editing and circulation have been described. These sophisticated processes vary with biological context and produce small RNAs with a wide range of sequence and spatial distributions. Statistical analysis of these variations from deep-sequencing data enables to identify the triggering biological perturbations; even at long distance from the initiator tissue if applied to circulating small RNAs.
In this scientific context, I will present our implementation of a versatile tool to detect and study phased biogenesis of viral derived siRNAs in mammals and endogenous siRNAs in Plants. Second half of the seminar will focus about our last work concerning new family of pseudogene derived siRNAs in Plants; their expression, tissue specificity and their probable role as translational repressor.


ICCP 2017

The International porphyrias & Porphyrins Congress will be in Bordeaux from 25 to 28 June 2017

ICCP 2017

INSERM U1035 - University of Bordeaux
146 rue Léo Saignat - PE building south zone, 4th floor
33000 Bordeaux
Work +33 557 57 13 73/74